Combinatorial transcription factor profiles predict mature and functional human islet α and β cells Shristi Shrestha, Diane C. Saunders, Jack T. Walker,… ,Patrick E. MacDonald, Shawn E. Levy, Alvin C. Powers, Marcela Brissova JCI Insight 2021;6(18):e151621.
α cell function and gene expression are compromised in type 1 diabetes Marcela Brissova, RachanaHaliyur, DianeSaunders, Shristi Shrestha, Chunhua Dai, David M.Blodgett, RitaBottino, Martha Campbell-Thompson, ……, MarkAtkinson, Alvin C.Powers Cell reports 22.10 (2018): 2667-2676.
The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity Samer G. Alam, Qiao Zhang, Nripesh Prasad, Yuan Li, Srikar Chamala, Ram Kuchibhotla, Birendra KC, Varun Aggarwal, Shristi Shrestha, Angela L. Jones, Shawn E. Levy, Kyle J. Roux, Jeffrey A. Nickerson & Tanmay P. Lele Scientific reports 6.1 (2016): 1-11.
SARS-CoV-2 cell entry factors ACE2 and TMPRSS2 are expressed in the microvasculature and ducts of human pancreas but are not enriched in β cells Katie C Coate, Jeeyeon Cha, Shristi Shrestha, …, Roland Stein, Klaus H Kaestner, Golnaz Vahedi, Marcela Brissova, Alvin C Powers, HPAP Consortium Cell metabolism 32.6 (2020): 1028-1040.
A molecular genetic basis explaining altered bacterial behavior in space Luis Zea, Nripesh Prasad, Shawn E Levy, Louis Stodieck, Angela Jones, Shristi Shrestha, David Klaus PloS one 11.11 (2016): e0164359.
Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks Rachana Haliyur, Xin Tong, May Sanyoura, Shristi Shrestha, Jill Lindner, Diane C Saunders, …, Roland W Stein, Marcela Brissova, Alvin C Powers The Journal of clinical investigation 129.1 (2019): 246-251.
Spaceflight modifies Escherichia coli gene expression in response to antibiotic exposure and reveals role of oxidative stress response Thomas R Aunins, Keesha E Erickson, Nripesh Prasad, Shawn E Levy, Angela Jones, Shristi Shrestha, Rick Mastracchio, Louis Stodieck, David Klaus, Luis Zea, Anushree Chatterjee Frontiers in microbiology 9 (2018): 310.
Ectonucleoside triphosphate diphosphohydrolase-3 antibody targets adult human pancreatic β cells for in vitro and in vivo analysis Diane C Saunders, Marcela Brissova, Neil Phillips, Shristi Shrestha, John T Walker, …, Shawn E Levy, Robert H Carnahan, Chunhua Dai, Jean Sévigny, Alvin C Powers Cell metabolism 29.3 (2019): 745-754
A high-throughput molecular data resource for cutaneous neurofibromas Sara JC Gosline, Hubert Weinberg, Pamela Knight, Thomas Yu, Xindi Guo, Nripesh Prasad, Angela Jones, Shristi Shrestha, Braden Boone, Shawn E Levy, Salvatore La Rosa, Justin Guinney, Annette Bakker Scientific data 4.1 (2017): 1-9.
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova,…, Zachary Freyberg Translational psychiatry 11.1 (2021): 1-18.
Single-cell sperm transcriptomes and variants from fathers of children with and without autism spectrum disorder Delia Tomoiaga, Vanessa Aguiar-Pulido, Shristi Shrestha, Paul Feinstein, Shawn E Levy, Christopher E Mason, Jeffrey A Rosenfeld NPJ genomic medicine 5.1 (2020): 1-7
Integrated analysis of the pancreas and islets reveals unexpected findings in human male with type 1 diabetes Rachana Haliyur, John T Walker, May Sanyoura, Conrad V Reihsmann, Shristi Shrestha, …., Marcela Brissova, Alvin C Powers Journal of the Endocrine Society 5.12 (2021): bvab162
RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes John T Walker, Diane C Saunders, Vivek Rai, Chunhua Dai, Peter Orchard, Alexander L Hopkirk, Conrad V Reihsmann, Yicheng Tao, Simin Fan, Shristi Shrestha, …., Stephen CJ Parker, Alvin C Powers, Marcela Brissova bioRxiv , 2021